Nuevas propuestas en el manejo médico y quirúrgico de metástasis de melanoma a cerebro

Daniela Carolina Bonilla Puentes; María Daniela Polanía Tovar; Natalia Imbachi Rebolledo; Angie Fernanda Urrego Henao

Nuevas propuestas en el manejo médico y quirúrgico de metástasis de melanoma a cerebro

Daniela Carolina Bonilla Puentes, María Daniela Polanía Tovar, Natalia Imbachi Rebolledo, Angie Fernanda Urrego Henao

Resumen

Introducción: El melanoma es la tercera causa más común de metástasis cerebral, después del cáncer de pulmón y cáncer de mama, con un pronóstico de supervivencia limitado y una elevada tasa de mortalidad. En este artículo se realizará una búsqueda de material literario acerca de los avances en el manejo médico y quirúrgico de pacientes con metástasis de melanoma cerebral. A lo largo del estudio, se desarrollarán descripciones de cada una de las posibles modalidades de tratamiento empleadas, avances y comparaciones en los resultados, relacionados con las tasas de respuesta general, supervivencia libre de progresión, supervivencia general y control a largo plazo.

Objetivo: Identificar las nuevas propuestas en el manejo clínico y quirúrgico de pacientes con melanoma metastásico a cerebro.

Método: Se realizó una búsqueda sistemática con las palabras claves en bases de datos PubMed, Cinicalkey, Medscape, Lilacs, The New England Journal of Medecine y Google Academics desde febrero 2018 hasta la fecha. Se encontró una amplia variedad de artículos dentro de los cuales se encuentran revisiones sistemáticas, reporte de casos, estudios retrospectivos, estudios multicéntricos y revisiones bibliográficas, se seleccionaron un total de 40 artículos, los cuales incluían el manejo convencional, avances en inmunoterapia y abordaje quirúrgico de las metástasis de melanoma a cerebro.

Palabras clave

Melanoma, metástasis cerebral, terapia sistémica, tratamiento quirúrgico, inmunoterapia.

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Referencias

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